Dr. phil. nat. Stefanie Seiler - Inselspital Bern - Neurochirurgie

Main Content

Dr. phil. nat. Stefanie Seiler

Post-Doctoral Fellow

Telefon: +41(0)31 632 10 64
Email: stefanie.seiler@insel.ch

Kurzes Profil:

Frau Stefanie Seiler hat Ihr Masterstudium der Biomedizinischen Wissenschaften im Dezember 2011 mit der Arbeit “Characterization of a mouse model to study the cognitive and neuropsychiatric symptoms of Parkinson’s disease.” abgeschlossen. Die Arbeit wurde am Karolinska Institute in Stockholm, Sweden, Department of Neuroscience, im Labor für molekulare Neuropharmakologie bei Herrn Prof. PhD Gilberto Fisone durchgeführt.
Sie war seit März 2012 als Doktorandin im Forschungslabor der Neurochirurgischen Klinik tätig. Ihre Dissertation mit dem Titel “The potential of Nogo-A neutralization as a novel treatment strategy for Parkinson’s disease” wurde unter der Leitung von Herrn Prof. Dr. H.R. Widmer durchgeführt. Frau Prof. Dr. Smita Saxena, Institut für Zellbiologie, Universität Bern war dabei als Ko-Referentin für die gcb verantwortlich.

Berufliche Stationen:

Seit 2016 Post Doc und Wissenschaftliche Mitarbeiterin der Universitätsklinik für Neurochirurgie des Inselspitals Bern
2012–2016 Doktorandin im Forschungslabor der Universitätsklinik für Neurochirurgie, Medizinische Fakultät der Universität Bern
2010–2011 Master Studium „Biomedical Sciences“ Universität Bern
2006–2010 Bachelor Studium „Biomedical Sciences“ Universität Fribourg
2002–2006 Gymnasium Lerbermatt, Köniz, BE

Mitgliedschaften:

Swiss Society for Neuroscience

Veröffentlichungen wissenschaftlicher Arbeiten

Die aktuellste Übersicht finden Sie hier unter Publikationen Stephanie Seiler in der Medline/PubMed (ein Service der U.S. National Library of Medicine und dem National Institutes of Health).

  1. Bonito-Oliva A, Pignatelli M, Spigolon G, Yoshitake T, Seiler S, Longo F, Piccinin S, Kehr J, Mercuri NB, Nisticò R, Fisone G (2013). Cognitive Impairment and Dentate Gyrus Synaptic Dysfunction in Experimental Parkinsonism. Biol Psychiatry doi: 10.1016/j.biopsych.2013.02.015.
  2. Seiler S, Pollini D, Di Santo S and Widmer HR (2013). Antagonizing Nogo-receptor 1 promotes the number of cultured dopaminergic neurons and elongates their neurites. NeuroReport 24(18): 1047-52.
  3. Di Santo S, Seiler S, Fuchs A-L, Staudigl J and Widmer HR (2014). The secretome of endothelial progenitor cells promotes brain endothelial cell activity through PI3-kinase and MAP-kinase. PLoS ONE April 22; 9(4): e95731.
  4. Seiler S and Widmer HR (2015). Nogo-A and its functions beyond axonal inhibition: The controversial role of Nogo-A in Parkinsons’s disease. Neural Regen Res 10(8): 1223-1224. doi: 10.4103/1673-5374.162749
  5. Seiler S, Di Santo S and Widmer HR (2015). Non-canonical actions of Nogo-A and its receptors. Biochem Pharmacol. 100: 28-39. doi: 10.1016/j.bco 2015.08.113.
  6. Liechti R, Ducray AD, Jensen P, Di Santo S, Seiler S, Jensen CH, Meyer M and Widmer HR (2015). Characterization of FA1/dlk1 expressing cells in the rat nigrostriatal system and effects of a 6-OHDA lesion. PLOS ONE Feb 27; 10(2): e0116088
  7. Schawkat K, Di Santo S, Seiler S, Ducray AD and Widmer HR (2015). Loss of Nogo-A expressing neurons in a rat model of Parkinson’s disease. Neuroscience 288: 59-72. doi:1001016/j.neuroscience 2014.12.035
  8. Di Santo S, Fuchs A-L, Periasamy R, Seiler S and Widmer HR (2016). The cytoprotective effects of Endothelial progenitor cells conditioned medium against an ischemic insult are not dependent on VEGF and IL-8. Cell Transplant. Jan 15, [Epub ahead of print] 25(4): 735-747.
  9. Seiler S, Di Santo S and Widmer HR (2016). Nogo-A neutralization improves graft function in a rat model of Parkinson’s disease. Front. Cell. Neurosci. 10:87.
  10. Di Santo S, Seiler S, Ducray AD, Meyer M and Widmer HR (2016). A subpopulation of dopaminergic midbrain neurons co-expresses serotonin in cultures of rat and human origin but not after transplantation in an animal model of Parkinson’s disease.  Cell Transpl. In press

Kongressbeiträge:

  1. M. Medová, S. Seiler, D. Leiser, W. Blank-Liss, B. Streit, D.M. Aebersold, Y. Zimmer (2010). MET receptor tyrosine kinase as a molecular target for sensitization of tumor cells to DNA damaging agents. Annual Meeting Day of Clinical research. University of Bern, Switzerland
  2. Di Santo S, Ducray A, Seiler S, Mina A, Raabe A and Widmer HR (2011). Paracrine factors secreted by Endothelial Progenitor Cells support viability of neuronal cells. Annual Meeting Swiss Society for Neuroscience, Basel, Switzerland.
  3. Seiler S, Fontana C, Andereggen L, Reinert M, Raabe A, Widmer HR and Di Santo S (2012). Factors secreted by endothelial progenitor cells promote brain endothelial cell tubulogenesis through PI3-kinase. Joint Meeting SSN / SBNS, Lugano, CH.
  4. Boujon V, Seiler S, Di Santo S, Raabe A, Widmer HR, Hermann D and Reitmeir R (2012). Characterization of spatio-temporal differentiation of neuronal and endothelial markers after vascular endothelial growth factor therapy in the ischemic brain. 74th Meeting of the SSAHE, Zurich, CH.
  5. Seiler S, Widmer HR, Raabe A and Di Santo S (2012). Paracrine factors released from endothelial progenitor cells demonstrate neuroprotection in an in vitro model of Parkinson’s disease. 74th Meeting of the SSAHE, Zurich, CH.
  6. Boujon V, Seiler S, Di Santo S, Raabe A, Widmer HR, Hermann D and Reitmeir R (2012). Vascular endothelial growth factor therapy improves neuronal survival and promotes angiogenesis in an ischemic mouse model. Annual Meeting of the Department of Clinical Research, University of Berne, Switzerland.
  7. Fontana C, Seiler S, Raabe A, Widmer HR and Di Santo S (2012). Expression pattern of angiogenin in the rat CNS. Annual Meeting of the Department of Clinical Research, University of Berne, Switzerland.
  8. Fuchs A-L, Seiler S, Fontana C, Raabe A, Widmer HR and Di Santo S (2012). PI3-kinase is critically involved in angiogenesis of brain endothelial cells induced by conditioned medium treatment. Annual Meeting of the Department of Clinical Research, University of Berne, Switzerland.
  9. Seiler S, Sahli S, Di Santo S, Porz N, Raabe A and Widmer HR (2012). NEP1-40 increases the number of dopaminergic neurons and their axon length in dissociated cultures of fetal ventral mesencephalon. Annual Meeting of the Department of Clinical Research, University of Berne, Switzerland.
  10. Porz N, Seiler S, Putzu A, Andres RH, Raabe A Widmer HR and Di Santo S (2012). Endothelial progenitor cell conditioned medium promotes endogenous neurogenesis in the subventricular zone. Annual Meeting of the Department of Clinical Research, University of Berne, Switzerland.
  11. Staudigl J, Fuchs A-L, Seiler S, Porz N, Widmer HR and Di Santo S (2012). Angiogenesis of brain endothelial cells is promoted by conditioned medium treatment. Annual Meeting Clinical Neuroscience, Bern, Switzerland.
  12. Porz N, Seiler S, Andres RH, Widmer HR and Di Santo S (2012). Increased endogenous neurogenesis in the rat subventricular zone by infusion of soluble factors derived from endothelial progenitor cell. Annual Meeting Clinical Neuroscience, Bern, Switzerland.
  13. 267.- Boujon V, Seiler S, Di Santo S, Staudigl J, Raabe A, Widmer HR and Reitmeir R (2012). Vascular endothelial growth factor therapy promotes neuronal plasticity in an ischemic mouse model. Annual Meeting Clinical Neuroscience, Bern, Switzerland.
  14. Seiler S, Sahli S, Di Santo S, Fuchs A-L, Porz N, Raabe A and Widmer HR (2012). Increased yield of dopaminergic neurons by antagonizing Nogo-receptor 1. Annual Meeting Clinical Neuroscience, Bern, Switzerland.
  15. Fontana C, Seiler S, Porz N, Widmer HR and Di Santo S (2012). Angiogenin is expressed in cholinergic and dopaminergic neurons. Annual Meeting Clinical Neuroscience, Bern, Switzerland.
  16. Di Santo S, Seiler S, Porz N, Ducray A, Raabe A and Widmer HR (2012). Neuroprotective capacity of endothelial progenitor cells in an in vitro model of Parkinson’s Disease. 22nd Annual Meeting NECTAR, Lund, Sweden.
  17. Porz N, Seiler S, Putzu A, Andres RH, Raabe A, Widmer HR and Di Santo S (2013). Intraventricular infusion of endothelial progenitor cell conditioned medium promotes endogenous neurogenesis. 9th Annual Meeting Swiss Stem Cell Network, Bern, Switzerland.
  18. Fuchs A-L, Staudigl J, Seiler S, Porz N, Widmer HR and Di Santo S (2013). Promotion of angiogenesis of brain endothelial cells induced by conditioned medium treatmen critically involves the PI3-kinase pathway. 9th Annual Meeting Swiss Stem Cell Network, Bern, Switzerland.
  19. Seiler S, Sahli S, Di Santo S and Widmer HR (2013). Antagonizing Nogo-A receptor NEP1-40 promotes survival and /or differentiation of cultured midbrain cells. Annual Meeting Swiss Society for Neuroscience, Geneva, Switzerland.
  20. Porz N, Seiler S, Putzu A, Andres R, Raabe A, Widmer HR and Di Santo S (2013). Induction of angiogenesis in the rat brain by endothelial progenitor cells-derived paracrine factors. Annual Meeting Swiss Society for Neuroscience, Geneva, Switzerland.
  21. Fuchs AL, Staudigl J, Seiler S, Porz N, Widmer HR and Di Santo S (2013). The Promotion of angiogenesis of brain endothelial cells by conditioned medium treatment critically involves the PI3-kinase pathway. Annual Meeting Swiss Society for Neuroscience, Geneva, Switzerland.
  22. Boujon V, Seiler S, Di Santo S, Raabe A,  Widmer HR, Herrmann DM and Reitmeir R (2013). Increased neurogenesis in the rat subventricular zone by infusion of soluble factors derived from endothelial progenitor cells. Annual Meeting Swiss Society for Neuroscience, Geneva, Switzerland.
  23. Porz N, Seiler S, Widmer HR and Di Santo S (2013). Increased neurogenesis in the rat subventricular zone by infusion of soluble factors derived from endothelial progenitor cells. ASNTR Ann. Meeting, Clearwater, FL, USA.
  24. Seiler S, Pollini D, Di Santo S and Widmer HR (2013). Antagonizing Nogo-receptor 1 promotes the number of cultured dopaminergic neurons and elongates their neurites. INTR12, Cardiff, Wales, UK.
  25. Di Santo S, Seiler S and Widmer HR (2013). Differential neuroprotective capacity of endothelial progenitor cells-derived factors. INTR12, Cardiff, Wales, UK.
  26. Fuchs A-L, Staudigl J,  Seiler S, Sahli S, Widmer HR and Di Santo S (2013). Modulation of the angiogenic properties of endothelial progenitor cells derived conditioned medium by culture conditions. Annual Meeting of the Department of Clinical Research, University of Berne, Switzerland.
  27. Nesti C, Seiler S, Widmer HR, Di Santo S and Andres R (2013). Effect of hemorrhage on neuronal progenitor cells in vitro. Annual Meeting of the Department of Clinical Research, University of Berne, Switzerland.
  28. Fontana C, Seiler S, Widmer HR and Di Santo S (2013). The angiogenic Rnase angiogenin is expressed by neurons in rat CNS. Annual Meeting of the Department of Clinical Research, University of Berne, Switzerland.
  29. Seiler S, Pollini D, Di Santo S and Widmer HR (2013). Increased dopaminergic cell number and neurite length by antagonizing Nogo-1 receptor. Annual Meeting of the Department of Clinical Research, University of Berne, Switzerland.
  30. Di Santo S, Seiler S and Widmer HR (2013). Neuroprotective properties of EPC-derived soluble factors. Annual Meeting of the Department of Clinical Research, University of Berne, Switzerland.
  31. Henzi A, Seiler S, Porz N, Widmer HR, Di Santo S (2014). Paracrine factors promote neurogenesis in the adult rat brain. Annual Meeting of the Swiss Society for Neuroscience, Berne, Switzerland.
  32. Seiler S, Pollini D, Di Santo S and Widmer HR (2014). Effects of antagonizing Nogo-1 receptor on survival and morphological differentiation of dopaminergic neurons in mesencephalic cultures. Annual Meeting of the Swiss Society for Neuroscience, Berne, Switzerland.
  33. Periasamy R, Fuchs AL, Seiler S, Widmer HR and Di Santo S (2014). Soluble factors derived from endothelial progenitors promote brain microvascular cell viability. Annual Meeting of the Swiss Society for Neuroscience, Berne, Switzerland.
  34. Periasamy R, Fuchs AL, Seiler S, Widmer HR and Di Santo S (2014). Analysis of the effects of conditioned medium from endothelial progenitors on brain microvascular cells. Annual ASNTR Meeting, Clearwater, FL, USA.
  35. Periasamy R, Fuchs AL, Seiler S, Widmer HR and Di Santo S (2014). Endothelial progenitors derived soluble factors promote brain microvascular cell viability. FENS Meeting, Milan, Italy.
  36. Seiler S, Polloni D, Di Santo S and Widmer HR (2014). Antagonization of Nogo-receptor 1 in combination with NT4/5 administration leads to higher dopaminergic cell densities as compared to single factor treatment. FENS Meeting, Milan, Italy.

Created by snowflake productions gmbh