Prof. Dr. Hans Rudolf Widmer - Inselspital Bern - Neurochirurgie

Contenu principal

Prof. Dr. Hans Rudolf Widmer

Leiter Forschungslabor für restorative Neurowissenschaften

Telefon: +41 (0)31 632 27 70
Email: hansrudolf.widmer@insel.ch

Besondere Schwerpunkte und Spezialisierungen

  • Restorative Neurologie
  • Neuronale Stammzellen
  • Rolle und Funktion von Wachstumsfaktoren während der Entwicklung und Differenzierung des Nervensystems
  • Hirnzelltransplantation beim Morbus Parkinson und dem Morbus Huntington
  • Neurotoxikologie und Neuroanatomie

Kurzes Profil

Prof. Dr. Hans Rudolf Widmer leitet seit 1996 das Forschungslabor der Neurochirurgischen Universitätsklinik. Der Schwerpunkt der Forschungstätigkeit von Prof. Dr. Hans Rudolf Widmer liegt im Gebiet der Restorativen Medizin und dabei speziell in der Entwicklung neuer Therapieansätze bei neurodegenerativen Erkrankungen. Er ist Mitglied von 10 nationalen und internationalen Fachgesellschaften. Seit vielen Jahren ist er an der Medizinischen Fakultät und der Naturwissenschaftlichen Fakultät in der Lehre aktiv und betreute bisher 20 Doktorarbeiten an der Medizinischen Fakultät. Prof. Dr. Hans Rudolf Widmer war Mitglied der Begleitgruppe der Studie ’Zelluläre Xenotransplantation’ des Schweizerischer Wissenschafts- und Technologierat in Bern und diente mehrere Jahre als Vorstandsmitglied des ’Network European CNS Transplantation and Restoration’ (NECTAR). Zurzeit ist er Mitglied der Kommission für Tierversuche des Kanton Berns und im Forschungsausschuss von Parkinson Schweiz. Er amtete als Vorsitzender und als Mitglied des ‘Scientific program committee’ an internationalen Kongressen. Prof. Dr. Widmer wurde im 2008 zum ‚Fellow of the American Society of Neural Therapy & Repair’ ernannt. Prof. Dr. Hans Rudolf Widmer hat 100 wissenschaftliche Arbeiten in Fachzeitschriften und als Buchbeiträge veröffentlicht, welche bisher über 3700 Mal zitiert wurden und ist Autor von mehr als 300 Kongressbeiträgen. Er ist Gutachter für nationale und internationale Forschungsprojekte und von über 30 internationalen renommierten Fachzeitschriften. Seit 2015 ist er Mitglied des Editorial Boards der Fachzeitschrift  ’Cell Transplantation’.

Berufliche Stationen

1996–dato Leiter Forschungslabor der Universitätsklinik für Neurochirurgie des Inselspitals Bern.
2008 Assoziierter Professor, Medizinische Fakultät der Universität Bern.
2003 Venia Docendi, Privatdozent für Neurowissenschaften, Medizinische Fakultät, Universität Bern
1993–1995 Wissenschaftlicher Assistent, Anatomisches Institut, Universität Bern
1991–1993 Research Fellow and Research Associate, Gerontology, University of Southern California, Los Angeles CA
1990 Wissenschaftlicher Assistent, Pharmakologisches Institut, Universität Zürich
1989 Promotion Dr. phil., Universität Zürich
1985–1989 Dissertation, Pharmakologisches Institut, Universität Zürich
1985 Diplom für das höhere Lehramt, Universität Zürich
1983 Dipl. phil. II, Universität Zürich
1978–1983 Studium der Biologie und Naturwissenschaften, Universität Zürich und ETH Zürich

Veröffentlichungen wissenschaftlicher Arbeiten

Die aktuellste Übersicht finden Sie hier unter Publikationen Prof. Hans Rudolf Widmer in der Medline/PubMed (ein Service der U.S. National Library of Medicine und dem National Institutes of Health).

Scientific Articles in Refereed Journals

  1. Lichtensteiger W, Ribary U, Schlumpf M, Odermatt B and Widmer HR (1988). Prenatal adverse effects of nicotine on the developing brain. Progress in Brain Research 73: 137-157.
  2. Widmer HR, Butikofer EE, Schlumpf M and Lichtensteiger W (1991). Pre- and postnatal lead exposure affects the serotonergic system in the immature rat brain. Experientia 47: 463-466.
  3. Widmer HR, Vedder H, Schlumpf M and Lichtensteiger W (1992). Concurrent changes in regional cholinergic parameters and nest odor preference in the early postnatal rat after lead exposure. Neurotoxicology 13: 615-625.
  4. Widmer HR, Knusel B and Hefti F (1992). Stimulation of phosphatidylinositol hydrolysis by brain-derived neurotrophic factor and neurotrophin-3 in rat cerebral cortical neurons developing in cultures. J. Neurochem. 59: 2113-2124.
  5. Knusel B, Beck KD, Winslow JW, Rosenthal A, Burton LE, Widmer HR, Nikolics K and Hefti F (1992). Brain-derived neurotrophic factor administration protects basal forebrain cholinergic but not nigral dopaminergic neurons from degenerative changes after axotomy in the adult rat.  J. Neurosci. 12: 4391-4402.
  6. Knusel B, Rabin S, Widmer HR, Hefti F and Kaplan DR (1992). Neurotrophin induced trk receptor phosphorylation and cholinergic neuron response in primary cultures of embryonic rat brain neurons. NeuroReport 3: 885-889.
  7. Widmer HR, Kaplan DR, Rabin SJ, Beck KD, Hefti F and Knusel B (1993). Rapid phosphorylation of phospholipase-C1 by BDNF and NT-3 in cultures of embryonic rat cortical neurons. J. Neurochem. 60: 2111-2123.
  8. Widmer HR, Ohsawa F, Knusel B and Hefti F (1993). Down-regulation of phosphatidylinositol response to BDNF and NT-3 in cultures of cortical neurons. Brain Res 614: 325-334.
  9. Widmer HR, Alexi T, Valverde J, Knusel B and Hefti F (1993). Transforming growth factor alpha stimulation of phosphatidylinositol hydrolysis in mesencephalic cultures requires neuron-glia interactions. Neuroreport 4: 407-410.
  10. Ohsawa F, Widmer HR, Knusel B, Denton T and Hefti F (1993). Response of embryonic rat hippocampal neurons in culture to neurotrophin-3, brain-derived neurotrophic factor and basic fibroblast growth factor. Neuroscience  57(1): 67-77.
  11. Widmer HR, Knusel B and Hefti F (1993). BDNF protection of basal forebrain cholinergic neurons after axotomy: complete protection of p75NGFR-positive cells. NeuroReport 4: 363-366.
  12. Widmer HR and Hefti F (1994). Stimulation of differentiation of GABA-ergic neurons by NT-4/5 in cortical cultures. Dev. Brain Res. 80: 279-284.
  13. Beck KD, Hefti F and Widmer HR (1994). Deafferentation removes calretinin immunopositive terminals, but does not induce degeneration of calbindin D-28k and parvalbumin expressing neurons in the hippocampus of adult rats. J. Neurosci. Res. 39: 298-304.
  14. Isono F, Widmer HR, Hefti F and Knusel B. (1994) Epidermal growth factor induces PC12 cell differentiation in presence of the protein kinase inhibitor K-252a. J. Neurochem. 63(4): 1235-1245.
  15. Widmer HR and Hefti F (1994). NT-4/5 promotes survival and differentiation of rat striatal neurons developing in cultures.  Eur. J. Neurosci. 6: 1669-1679.
  16. Heider H and Widmer HR (1995)  Okadaic acid potentiates heat-induced activation of erk2.  Biochim. Biophys. Acta 1265: 196-200.
  17. Beck KD, Powell-Braxton L, Widmer HR, Valverde J and Hefti F. (1995) Mice homozygous for disrupted insulin-like growth factor I gene display reduced myelination in the CNS and reduced numbers of hippocampal granule and striatal parvalbumin-containing neurons.  Neuron 14: 717-730.
  18. Dugich-Djordjevic MM, Peterson C, Isono F, Ohsawa F, Widmer HR, Denton T, Bennet GL and Hefti F. (1995) Immunohistochemical visualization of brain-derived neurotrophic factor in the rat brain. Eur. J. Neurosci. 7(9): 1831-1839.
  19. Chan K-M, Lam D-TN, Pong K, Widmer HR and Franz Hefti (1996) Neurotrophin-4/5 treatment reduces infarct size in rats with middle cerebral artery occlusion. Neurochem. Res. 2 (7): 763-767.
  20. Puntschart A, Vogt M, Widmer HR, Hoppeler H and Billeter R. (1996). Hsp70 expression in human skeletal muscle after exercise.    Acta Physiol. Scand.157: 411-417.
  21. Gnehm P, Reichenbach S, Altpeter E, Widmer H and Hoppeler H. (1997). Influence of different racing positions on metabolic cost in elite cyclists.    Med. Sci. Sports Exerc. 29(6): 818-823.
  22. Widmer HR, Hoppeler H, Nevo E, Taylor CR and Weibel ER. (1997). Working underground: Respiratory adaptations in the blind mole rat.    PNAS  94: 2062-2067.
  23. Meyer M, Widmer HR, Wagner B, Guzman R, Evtouchenko L, Seiler RW and Spenger C (1998). Comparison of mesencephalic free floating tissue culture grafts and cell suspension grafts in the 6-hydroxydopamine lesioned rat.  Exp. Brain Res.   119(3):  345-355.
  24. Sautter J, Tseng J, Braguglia D, Aebischer P, Spenger C, Seiler R, Widmer HR and A. Zurn (1998). Implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor improve survival, growth and function of fetal dopaminergic grafts. Exp. Neurol. 149: 230-236.
  25. Puntschart A, Wey E, Jostarndt K, Vogt M, Wittwer M, Widmer HR, Hoppeler H and Billeter R (1998). The expression of the fos and jun genes in human skeletal muscle after exercise.   Am. J. Physiol. 274(Cell. Physiol. 43): C129-C37.
  26. Sautter J, Meyer M, Spenger C, Seiler RW and Widmer HR (1998). Effects of combined BDNF and GDNF treatment on cultured dopaminergic midbrain neurons. NeuroReport  9(6): 1093-1096.
  27. Höglinger G, Sautter J, Meyer M, Spenger C, Seiler RW, Oertel WH and Widmer HR (1998). Rat fetal ventral mesencephalon grown as solid tissue cultures: Influence of culture time and BDNF treatment on dopamine neuron survival and function.   Brain Res. 813: 313-322.
  28. Guzman R, Meyer M, Lövblad KO, Ozdoba C, Schroth G, Seiler RW and Widmer HR (1999). Striatal grafts in a rat model of Huntington’s disease: Time course comparison of MRI and histology. Exp. Neurol.156: 180-190.
  29. Meyer M, Zimmer J, Seiler RW and Widmer HR (1999). GDNF increases the density of cells containing calbindin but not of cells containing calretinin in cultured fetal nigral tissue. Cell Transpl. 8: 25-36.
  30. Widenfalk J, Widmer HR and Spenger C (1999). GDNF and GDNF related receptors expression in human embryonic spinal cord.  NeuroReport 10: 1433-1439.
  31. Guzman R, Lövblad KO, Meyer M, Spenger C, Schroth G, and Widmer HR (2000). Imaging the rat brain on a 1.5T clinical MR-Scanner.   J. Neurosci. Method.  97(1): 77-85.
  32. Bauer M, Meyer M, Grimm L, Meitinger T, Zimmer J, Gasser T, Ueffing M and Widmer HR (2000). Non-viral GDNF gene transfer enhances survival of cultured dopaminergic neurons and improves their function and survival after transplantation in a rat model of Parkinson's disease. Human Gene Therapy 11: 1529-1541.
  33. Widmer HR, Schaller, B, Meyer M and Seiler RW (2000). Glial cell line-derived neurotrophic factor stimulates the morphological differentiation of cultured ventral mesencephalic  calbindin and calretinin expressing neurons. Exp. Neurol. 164: 71-81.
  34. Höglinger GU, Widmer HR, Spenger C, Meyer M, Seiler RW, Oertel WH, and Sautter J (2001). Influence of time in culture and BDNF pre-treatment on survival and function of grafted embryonic rat ventral mesencephalon in the 6-OHDA rat model of Parkinson’s disease. Exp. Neurol. 167:148-157.
  35. Josephson A, Widenfalk J, Widmer HR, Olson L and Spenger C (2001). NOGO mRNA expression in adult and fetal human and rat nervous tissue and in weight drop injury.   Exp. Neurol. 169(2): 319-328.
  36. - Bauer M, Meyer M, Sautter J, Gasser T, Ueffing M and Widmer HR (2001). Liposome-mediated gene transfer to fetal human ventral mesencephalic explant cultures. Neurosci. Lett. 308(3): 169-172.
  37. Josephson A, Widenfalk J, Trifunovski A, Widmer HW, Olson L and Spenger C (2001). GDNF and NGF family members and receptors in human fetal and adult spinal cord and dorsal root ganglia.    J. Comp. Neurol. 440: 204-217.
  38. Meyer M, Matarredona ER, Seiler RW, Zimmer J and Widmer HR (2001). Additive effect of glial cell line-derived neurotrophic factor and neurotrophin-4/5 on rat fetal nigral explant cultures.   Neuroscience  108(2): 273-284.
  39. Josephson A, Trifunovski A, Widmer HR, Widenfalk J, Olson L and Spenger C (2002). NOGO receptor gene activity: cellular localization and developmental regulation of mRNA in mice and humans. J. Comp. Neurol.  453: 292-304.
  40. Bauer M, Suppmann S, Meyer M, Hesslinger C, Gasser T, Widmer HR and Ueffing M (2002). Glial cell line-derived neurotrophic factor up-regulates GTP-cyclohydrolase I activity and tetrahydrobiopterin levels in primary dopaminergic neurons. J. Neurochem. 82(5): 1300-1320.
  41. Bauer M, Meyer M, Brevig T, Gasser T, Widmer HR,  Zimmer J and Ueffing M (2002). Lipid-mediated glial cell-line derived neurotrophic factor gene transfer to cultured porcine ventral mesencephalic tissue.  Exp. Neurol. 177: 40-49.
  42. Rodriguez-Matarredona E, Meyer M, Seiler RW and Widmer HR (2003). CGP3466 increases survival of cultured fetal dopaminergic neurons.   Rest. Neurol. Neurosci. 21: 29-37.
  43. Reinert M, Schaller B, Widmer HR, Seiler R and Bullock R (2004). Oxygen therapy improves glucose-lactate metabolism after diffuse brain injury. J. Neurosurgery 101: 323-329.
  44. Zihlmann KB, Ducray A, Schaller B, Huber AW, Krebs SH, Andres RH, Seiler RW, Meyer M and Widmer HR (2005). The GDNF family members Neurturin, Persephin and Artemin promote the morphological differentiation of cultured nigral dopaminergic neurons. Brain Res. Bull. 68: 42-53.
  45. Schaller, B, Andres R, Huber AW, Meyer M, Pérez-Bouza A, Ducray AD, Seiler RW and Widmer HR (2005). Effect of GDNF on differentiation of dopaminergic and non-dopaminergic calretinin expressing neurons in mesencephalic cultures. Brain Res.1036 (1-2): 163-172.
  46. Andres RH, Ducray AD, Pérez-Bouza A, Schlattner U, Huber AW, Krebs S, Seiler RW, Wallimann T and Widmer HR (2005). Creatine supplementation improves dopaminergic cell survival and protects against MPP+ toxicity in an organotypic tissue culture system. Cell Transplantation 14 (8): 537-550.
  47. Andres RH, Huber AW, Pérez-Bouza A, Schlattner U, Krebs S, Ducray AD, Seiler RW, Wallimann T and Widmer HR (2005). Effects of creatine treatment on survival and differentiation of dopaminergic neurons in cultured fetal ventral mesencephalic tissue. Neuroscience 133: 701-713.
  48. Andres RH, Ducray AD, Huber AW, Pérez-Bouza A, Krebs S, Schlattner U, Seiler RW, Wallimann T and Widmer HR (2005). Effects of creatine treatment on survival and differentiation of GABAergic neurons in cultured striatal tissue. J. Neurochem. 95: 33-45.
  49. Ducray AD, Kipfer S, Huber AW, Andres RH, Seiler RW, Schlattner U, Wallimann T and Widmer HR (2006). Creatine and neurotrophin-4/5 promote survival of nitric oxide sythase expressing interneurons in striatal cultures. Neurosci. Lett. 395 (1): 57-62.
  50. Bauer M, Kristensen BW, Meyer M, Gasser T, Widmer HR, Zimmer J and Ueffing M (2006). Toxic effects of lipid-mediated gene transfer in ventral mesencephalic explant cultures. Basic Clin Pharmacol. Toxicol. 98(4): 395-400.
  51. Ducray A, Krebs SH, Schaller B, Seiler R, Meyer M and Widmer HR (2006). GDNF family ligand display distinct action profiles on cultured GABAergic and serotonergic  neurons of rat ventral mesencephon. Brain Res. 1069 (1): 104-112.
  52. Jensen P, Bauer M, Jensen CH, Widmer HR, Blaabjerg M, Zimmer J and Meyer M (2007). Expansion and characterization of ventral mesencephalic progenitor cells: Influence of mitogens and investigation of FA1 as a potential dopaminergic marker. J. Neurosci. Res.  85: 1884-1893.
  53. Barth A, Guzman R, Andres RH, Mordasini P, Barth L and Widmer HR (2007). Experimental intracerebral hemorrhage combining focal trauma and blood infusion in the rat brain. Rest. Neurol. Neurosci   25: 1-7.
  54. Ducray AD, Qualls R, Schlattner U, Andres RH, Dreher E, Seiler RW, Wallimann T and Widmer HR (2007). Creatine promotes the GABAergic phenotype in fetal human spinal cord cultures. Brain Res. 1137: 50-57.
  55. Ducray AD, Schlaeppi JA, Qualls R, Andres RH, Seiler RW, Schlattner U, Wallimann T and Widmer HR (2007). Creatine treatment promotes differentiation of GABAergic neuronal precursors in cultured fetal spinal cord. J. Neurosci. Res. 85: 1863-1875.
  56. Reinert M, Andres R, Fuhrer M, Müller A, Schaller B and Widmer HR (2007). Online correlation of spontaneous arterial and intracranial pressure fluctuations in patients with diffuse severe head injury. Neurological Research  29(5): 455-62.
  57. Taussky P, Widmer HR, Takala J and Fandino J (2008). Outcome after acute traumatic subdural and epidural hematoma in Switzerland: A single center experience. Swiss Medical Weekly  138(19-20): 281-85.
  58. Alfieri A, Unterhuber V, Pircher M, Schwarz A, Gazzeri R, Reinert M and Widmer HR (2008). Psychosocial and neurocognitive performances after spontaneous nonaneurysmal subarachnoid hemorrhage are related to the APO E 4 genotype. A prospective five-year follow-up study.  J. Neurosurgery  109: 1014-1026.
  59. Jensen P, Pedersen EG, Widmer HR, Zimmer J and Meyer M (2008). Functional effect of FGF2 and FGF8 expanded ventral mesencephalic precursor cells in a rat model of Parkinson’s disease. Brain Res.  Jul 7;1218: 13-20.
  60. Sury MD, Agarinis C, Widmer HR, Leib S and Christen S (2008). JNK is activated but does not mediate hippocampal neuronal apoptosis in experimental neonatal pneumococcal meningitis. Neurobiol. Disease Oct;32(1):142-50.
  61. Andres RH, Barth A, Guzman R, Remonda L, El-Koussy M, Seiler RW, Widmer HR and Schroth G (2008). Endovascular and surgical treatment of spinal dural arteriovenousus fistulas. Neuroradiology  50(10): 869-76.
  62. Andereggen L, Meyer M, Guzman R, Ducray AD and Widmer HR (2009). Effects of GDNF pretreatment on function and survival of transplanted fetal ventral mesencephalic cells in the 6-OHDA rat model of Parkinson’s disease. Brain Res 1276: 39-49.
  63. Andersen RK, Widmer HR, Zimmer J, Wahlberg LU and Meyer M (2009). Leukemia inhibitory factor induces tyrosine hydroxylase expression in long-term propagated human midbrain precursor cells.  Neurosci. Lett. 464: 203-208.
  64. Jensen P, Gramsbergen JB, Zimmer J, Widmer HR and Meyer M (2011). Enhanced proliferation and dopaminergic differentiation of ventral mesencephalic precursor cells by synergistic effect of FGF2 and reduced oxygen tension. Exp. Cell Res. 317(12):1 649-1662.
  65. Schlachter EK, Widmer HR, Bregy A, Lönnfors-Weitzel T, Vajtai I,  Corazza N, Vianney Bernau JP, Weitzel T, Mordasini P,  Slotboom J,  Herrmann G, Bogni S, Hofmann H, Frenz M and Reinert M (2011). Metabolic Pathway and Distribution of Superparamagnetic Iron Oxide Nanoparticles: A Long-term in-vivo Study. International Journal of Nanomedicine  6: 1793–1800.
  66. Andereggen L, Schroth G, Gralla J, Seiler R, Mariani L, Beck J, Widmer HR, Andres RH, Christ E and Ozdoba C (2012). Selective inferior petrosal sinus sampling without venous outflow diversion in the detection of a pituitary adenoma in Cushing’s syndrome. Neuroradiology 54 (5); 495-503.
  67. Tokarska-Schlattner M, Epand RF, Meiler F, Zandomeneghi G, Neumann D, Widmer HR, Meier BH, Epand RM, Saks V, Wallimann T and Schlattner U (2012). Phosphocreatine interacts with phospholipids, affects membrane properties and exerts cell-protective effects. PLoS ONE 7(8): e43178.
  68. Marbacher S, Andereggen L, Neuschmelting V, Widmer HR, von Gunten M, Takala J, Jakob S and Fandino J (2012). A new rabbit model for the study of early brain injury after subarachnoid hemorrhage. J. Neurosci. Methods 208(8): 138-145.
  69. Schmidt J, Murek M, Jilch A, Widmer HR, Schucht P, Beck J and Raabe A (2012). Conscious operation: The patient perspective. Brain exposed patient during awareness.   Pflege Z. 65(2): 76 - 8.
  70. Maroof AM, Keros S, Ying SW, Ganat YM, Tyson JA, Liu R, Goulbrun A, Widmer HR, Goldstein PA, Anderson S and Studer L (2013). Directed differentiation of human pluripotent stem cells into cortical interneurons. Cell Stem Cell 12(5): 559-72.
  71. Jensen P, Heimberg M, Ducray AD, Widmer HR and Meyer M (2013). Expression of Trefoil factor 1 in the developing and adult rat ventral mesencephalon. PLoS ONE  Oct 7; 8(10): e76592.
  72. Seiler S, Pollini D, Di Santo S and Widmer HR (2013). Antagonizing Nogo-receptor 1 promotes the number of cultured dopaminergic neurons and elongates their neurites. NeuroReport 24(18): 1047-52.
  73. Di Santo S, Mina A, Ducray AD, Widmer HR and Senn P (2013). Creatine supports propagation of inner ear-derived progenitor cells and promotes differentiation into neuronal cell types. NeuroReport 25(7): 446-51.
  74. Di Santo S, Seiler S, Fuchs A-L, Staudigl J and Widmer HR (2014). The secretome of endothelial progenitor cells promotes brain endothelial cell activity through PI3-kinase and MAP-kinase. PLoS ONE April 22; 9(4): e95731.
  75. Andereggen L, Neuschmelting V, von Gunten M, Widmer HR, Fandino J and Marbacher S (2014). The role of microclot formation in an acute subarachnoid hemorrhage model in the rabbit. BioMed Research International, Vol. 2014, Article ID 161702, 10 pages, doi:10.1155/2014/161702.
  76. Andereggen L, Neuschmelting V, von Gunten M, Widmer HR, Takala J, Jakob S Fandino J and Marbacher S (2014). The rabbit blood-shunt model for the study of acute and late sequelae of subarachnoid hemorrhage: Technical aspects. JoVE Oct 2; (92): doi: 10.3791/52132
  77. Marbacher S, Andereggen L, Neuschmelting V, Widmer HR, von Gunten M, Takala J, Jakob S and Fandino J (2014). Early brain injury linearly correlates with reduction in cerebral perfusion pressure during the hyperacute phase of subarachnoid hemorrhage. Intensive Care Med. Exp. 2: 30.
  78. Liechti R, Ducray AD, Jensen P, Di Santo S, Seiler S, Jensen CH, Meyer M and Widmer HR (2015). Characterization of FA1/dlk1 expressing cells in the rat nigrostriatal system and effects of a 6-OHDA lesion. PLOS ONE Feb 27; 10(2): e0116088
  79. Marbacher S, Fathi AR, Muroi C, Coluccia D, Andereggen L, Neuschmelting V, Widmer HR, Jakob S and Fandino J (2015). The rabbit blood-shunt subarachnoid haemorrhage model. Acta Neurochir Suppl 120: 337- 42.
  80. Schawkat K, Di Santo S, Seiler S, Ducray AD and Widmer HR (2015). Loss of Nogo-A expressing neurons in a rat model of Parkinson’s disease. Neuroscience 288: 59-72. doi:1001016/j.neuroscience 2014.12.035
  81. Krähenbühl AK, Gralla J, Abu-Isa J, Mordasini P, Widmer HR, Raabe A and Reinert M (2015). High-flow venous pouch aneurysm in the rabbit carotid artery: A model for large aneurysms.  Interv. Neuroradiol. May 26. pii: 1591019915582381
  82. Andereggen L, Vajtai I, Widmer HR, Raabe A and Andres RH (2015). Rapid recurrence of a benign meningial perineurioma. World Neurosurg. June 10. pii: S1878-8750(15)00708-1.
  83. Jensen P, Ducray AD, Widmer HR and Meyer M (2015). Effects of forskolin on Trefoil factor 1 expression in cultured ventral mesencephalic dopaminergic neurons. Neuroscience 310: 699-708.
  84. Hahnewald S, Tscherter A, Marconi E, Streit J, Widmer HR, Garnham C, Benav H, Mueller M, Löwenheim H, Roccio M and Senn P (2016). Response profiles of murine spiral ganglion neurons on multi-electrode arrays.  J. Neural Eng.13 (1): 016011.
  85. Di Santo S, Fuchs A-L, Periasamy R, Seiler S and Widmer HR (2016). The cytoprotective effects of Endothelial progenitor cells conditioned medium against an ischemic insult are not dependent on VEGF and IL-8. Cell Transplant. Jan 15, [Epub ahead of print] 25(4): 735-747.
  86. Andereggen L, Gralla J, Andres RH, Weber S, Schroth G, Beck J, Widmer HR, Reinert M, Raabe A and Peterhans M (2016). Stereolithographic models in the interdisciplinary planning of treatment for complex intracranial aneurysms.  Acta Neurochir. 158(9): 1711-20.
  87. Zuccarella-Hackel C, von Känel R, Thomas L, Hauser M, Kuebler U, Widmer HR and Wirtz PH (2016). Higher macrophage superoxide anion production in essential hypertension. Associations with biological and psychological cardiovascular risk factors. Psychosomatic Medicine 78(6): 750-7.
  88. Seiler S, Di Santo S and Widmer HR (2016). Nogo-A neutralization improves graft function in a rat model of Parkinson’s disease. Front. Cell. Neurosci. 10:87.
  89. Andres R, Ducray AD, Andereggen L, Hohl T, Schlatter U, Wallimann T and Widmer HR (2016). The effects of creatine supplementation on striatal neural progenitor cells depend on developmental stage. Amino Acids 48(8): 1913-27.
  90. Ducray AD, Stojiljkovic A, Moeller A, Stoffel M, Widmer HR, Frenz M and Mevissen M (2016). Silica nanoparticles for tissue soldering in the brain; uptake and impact on neuronal differentiation.  Nanomedicine  In press   
  91. Di Santo S, Seiler S, Ducray AD, Meyer M and Widmer HR (2016). A subpopulation of dopaminergic midbrain neurons co-expresses serotonin in cultures of rat and human origin but not after transplantation in an animal model of Parkinson’s disease.  Cell Transpl. In press 

Reviews in Refereed Journals

  1. Zurn AD, Widmer HR, Aebischer P (2001). Sustained delivery of GDNF: Towards a treatment for Parkinson's disease. Brain Res Brain Res Rev. Oct;36(2-3): 222-9.
  2. Andres RH, Meyer M, Ducray AD and Widmer HR (2008). Restorative neuroscience: Concepts and perspectives. Swiss Medical Weekly 38(11-12): 155-72.
  3. Andres RH, Guzman R, Ducray AD, Mordasini P, Gera A, Barth A, Widmer HR and Steinberg GK (2008). Cell Replacement Therapy and Neuroprotection for Intracerebral Hemorrhage. Neurosurgical Focus  24(3-4): E16.
  4. Andres R, Ducray AD, Schlattner U, Wallimann T and Widmer HR (2008). Functions and effects of creatine in the central nervous system. Brain Res. Bull.   76(4): 329-343.
  5. Seiler S and Widmer HR (2015). Nogo-A and its functions beyond axonal inhibition: The controversial role of Nogo-A in Parkinsons’s disease. Neural Regen Res 10(8): 1223-1224.
  6. Seiler S, Di Santo S and Widmer HR (2015). Non-canonical actions of Nogo-A and its receptors. Biochem Pharmacol. 100: 28-39.
  7. Di Santo S and Widmer HR (2016). Paracrine factors for neurodegenerative disorders: Special emphasis on Parkinsons’s disease. Neural Regen Res 11(4): 570-571. doi: 10.4103/1673-5374.180739
  8. Andres R, Wallimann T and Widmer HR (2016). Creatine supplementation improves neural progenitor cell survival in Huntington’s disease. Brain Circ. 2(3): 133-

Übersichtsarbeiten

  1. Wallimann T, Tokarska-Schlattner M, Neumann D, Epand RM, Epand RF, Andres RH, Widmer HR, Saks V, Agarkova I and Schlattner U. The phospho-creatine Circuit: Molecular and cellular physiology of creatine kinases, sensitivity to free radicals and enhancement by creatine supplementation. In: Molecular Systems Bioenergetics. Ed. Saks V, Wiley. pp 195 – 264 (2007).
  2. Andres RH, Guzman R, Ducray AD, Mordasini P, Gera A, Barth A, Widmer HR and Steinberg GK. Cell replacement therapy for intracerebral hemorrhage. Neurosurgical Focus  24(3-4): E16 (2008).
  3. Andres R, Ducray AD, Schlattner U, Wallimann T and Widmer HR. Functions and effects of creatine in the central nervous system. Brain Res. Bull. 76(4): 329-343 (2008).  
  4. Andres RH, Meyer M, Ducray AD and Widmer HR. Restorative neuroscience: Concepts and perspectives. Swiss Medical Weekly 38(11-12): 155-72 (2008).

Book chapters

  1. Hefti F, Venero JL, Widmer HR and Knusel B (1995). Nerve growth factor therapy for Alzheimer’s disease: comparison with brain-derived neurotrophic factor. In Iqbal K, Mortimer JA, Winblad B and Wisniewski HM (eds). Research advances in Alzheimers’s disease and related disorders. John Wiley & Sons. Chichester, pp 321-328.
  2. Hefti F, Wei-Qiang G, Nikolics K, Rosenthal A, Shelton D, Phillips HS, Treanor JJS, Chan K-M, Widmer HR, Rask C, Burton GL and Winslow JW (1995). Therapeutic use of neurotrophic factors. In Ibanez CF, Hokfelt T, Olson L, Fuxe K, Jornvall H and Ottoson D (eds). Life and Death in the Nervous System, Part VI: Neurotrophic Factor Function In Vivo: Degeneration and Regeneration (Elsevier; ISBN: 978-0-08-042527-6), 12: pp 379-390.
  3. Billeter R, Puntschart A, Vogt M, Widmer HR and Hoppeler H (1996). Trainingsanpassung - eine Frage der Genregulation (Training adaptation - based on the regulation of genes). In: Tagungsbericht der 5. Sportwissenschaftlichen Hochschultage (Reports of the 5th Swiss Sports Science Conference), K. Egger (editor) pp 39-43.
  4. Spenger C, Widmer HR and Studer L (1999). Human and rat neurons in roller tube cultures. In: The neuron in Tissue Culture. Ed. L. Haynes, IBRO Handbook Series, John Wiley. pp 684-692.
  5. Bensadoun JC, Widmer HR, Zurn AD and Aebischer P (2000). Polymer Encapsulated Cells as a Tool for Drug Delivery and Neural Transplantation in Parkinson's Disease. In: Principles of Surgery for Parkinson's Disease and Movement Disorders. Eds. JK Krauss, J Jankovic, RG Grossman. Lippincott, Williams & Wilkins.
  6. Wallimann T, Tokarska-Schlattner M, Neumann D, Epand RM, Epand RF, Andres RH, Widmer HR, Saks V, Agarkova I and Schlattner U (2007). The phospho-creatine Circuit: Molecular and cellular physiology of creatine kinases, sensitivity to free radicals and enhancement by creatine supplementation. In: Molecular Systems Bioenergetics. Ed. Saks V, Wiley. pp 195 - 264.

Reviews

  1. Widmer HR (2003). Hirnzelltransplantation als neue Behandlungsoption? Ärztliche Praxis Neurologie Psychiatrie Jan/Feb; 1: 30-32.
  2. Widmer HR, Ducray AD, Schaller B, Andres RH, Krebs SH, Zihlmann K and Seiler RW (2004). Wachstumsfaktoren für das Gehirn. UniPress 120: 14-17.
  3. Reinert M, Frenz M, Widmer HR, Barth A and Seiler R (2004). Hirn-Bypass Operation: Eine Neu-Entwicklung. UniPress 120: 18-20.

Other Publications

  1. Reichenbach S, Gnehm P, Widmer HR, Altpeter E, Bergmaier G and  Hoppeler H (1995). Einfluss der Aeroposition auf das Pedalkraftmuster im Radrennsport.     Schweiz. Zeitschr. Sportmed. Sporttraumatol. 1: 8 -13.
  2. Hahnewald S, Roccio M, Marconi E, Garnhalm C, Mistrik P, Tscherter A, Streit J, Brossard J, Homsy A, Keppner H, Widmer HR and Senn P (2014). Response profile of auditory neurons on multi-electrode arrays. Proceedings Book of the MEA meeting (9th international meeting on substrate-integrated microelectrode arrays).  
  3. Shoaran M, Yilmaz G, Periasamy R, Seiler S, Di Santo S, Pollo C, Widmer HR, Dehollain C and Schmid A (2014). In-vivo validation of a compact inductively-powered neural recording interface. BioCAS Conference, Lausanne, CH, October 22-24.

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