Prof. Dr. med. Werner Z'Graggen

Médecin chef de service de soins neuro-intensifs

Langues: Allemand, Français, Italien, Anglais


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«Poster Prize»: Swiss Society for Clinical Neurophysiology 2006: Repetitive spinal motor discharges following transcranial magnetic stimulation: relation to handedness; Z’Graggen WJ, Humm AM, Oppliger-Bachmann S, Hosang M, Rösler KM


«Dejerine-Dubois-Preis»: 176th Meeting of Swiss Society for Neurology 2005: Functional organization of the human primary motor cortex; Z’Graggen WJ, Bastos-Conforto A, Hess CW, Kaelin-Lang A


«Semester Preis»: Fakultät für Medizin, Universität Zürich, für Doktorarbeit: «Plasticity of Corticofugal Projections in Adult Rats by Blockade of Myelin-Associated Neurite Growth Inhibitors»

Toutes les publications

  1. Häni L, Ropelato M, Wagner F, Nowacki A, Söll N, Hänggi M, Raabe A, Z'Graggen W. ‌Individualized Brain Tissue Oxygen-Monitoring Probe Placement Helps to Guide Therapy and Optimizes Outcome in Neurocritical Care Neurocrit Care. 2021 Aug;35:197-209.
  2. Seidel K, Jeschko J, Schucht P, Bervini D, Fung C, Krejci V, Z'Graggen W, Fischer U, Arnold M, Goldberg J, Raabe A, Beck J. ‌Somatosensory Evoked Potential and Transcranial Doppler Monitoring to Guide Shunting in Carotid Endarterectomy. J Neurol Surg A Cent Eur Neurosurg. 2021 Jul; 82(04):299-307.
  3. Müller M, Rossetti A, Zimmermann R, Alvarez V, Rüegg S, Hänggi M, Z'Graggen W, Schindler K, Zubler F. ‌Standardized visual EEG features predict outcome in patients with acute consciousness impairment of various etiologies Crit Care. 2020 Dec 7;24(1):680
  4. Schatlo B, Fung C, Stienen M, Fathi A, Fandino J, Smoll N, Zumofen D, Daniel R, Burkhardt J, Bervini D, Marbacher S, Reinert M, d'Alonzo D, Ahlborn P, Mendes Pereira V, Röthlisberger M, Seule M, Kerkeni H, Remonda L, Weyerbrock A, Woernle K, Venier A, Perren F, Sailer M, Robert T, Rohde V, Schöni D, Goldberg J, Nevzati E, Diepers M, Gralla J, Z'Graggen W, Starnoni D, Woernle C, Maldaner N, Kulcsar Z, Mostaguir K, Maduri R, Eisenring C, Bernays R, Ferrari A, Danura H, Finkenstädt S, Sarrafzadeh A, Jakob S, Corniola M, Baumann F, Regli L, Levivier M, Hildebrandt G, Landolt H, Mariani L, Guzman R, Beck J, Raabe A, Bijlenga P, Schaller K. ‌Incidence and Outcome of Aneurysmal Subarachnoid Hemorrhage: The Swiss Study on Subarachnoid Hemorrhage (Swiss SOS) Stroke. 2021 Jan;52(1):344-347.
  5. Häni L, Vulcu S, Branca M, Fung C, Z'Graggen W, Murek M, Raabe A, Beck J, Schucht P. ‌Subdural versus subgaleal drainage for chronic subdural hematomas: a post hoc analysis of the TOSCAN trial. J Neurosurg.2020 Oct;133(4):1147-1155.
  6. Contartese J, Z'Graggen W, Hämmerli B, Lavina L. ‌Intermediate Care Units: Vielfältige Stationen mit Zukunft Schweiz Ärzteztg. 2020;101(40):1281-1282
  7. Schefold J, Wollersheim T, Grunow J, Luedi M, Z'Graggen W, Weber-Carstens S. ‌Muscular weakness and muscle wasting in the critically ill. J Cachexia Sarcopenia Muscle. 2020 Sep 7.
  8. Liu S, do Amaral C, Pedro P, Casoni D, Berger D, Kohler A, Bloch A, Bervini D, Setzer F, Cameron D, Z'Graggen W, Hana A, Langer R, Corrêa T, Beldi G, Takala J, Jakob S. ‌Defense mechanisms to increasing back pressure for hepatic oxygen transport and venous return in porcine fecal peritonitis. Am J Physiol Gastrointest Liver Physiol. 2020 Sep 1;319(3):G289-G302.
  9. Häni L, Fung C, Jesse C, Ulrich C, Miesbach T, Cipriani D, Dobrocky T, Z'Graggen W, Raabe A, Beck J, Piechowiak E. ‌Insights into the natural history of spontaneous intracranial hypotension from infusion testing. Neurology. 2020 Jul 21;95(3):e247-e255
  10. Tankisi H, de Carvalho M, Z'Graggen W. ‌Critical Illness Neuropathy Clin Neurophysiol. 2020 May; 37(3):205-207.
Voir plus
  1. Schär R, Tashi S, Branca M, Söll N, Cipriani D, Schwarz C, Pollo C, Schucht P, Ulrich C, Beck J, Z'Graggen W, Raabe A. ‌How safe are elective craniotomies in elderly patients in neurosurgery today? A prospective cohort study of 1452 consecutive cases. J Neurosurg. 2020 Apr 24;1-9.
  2. Witt A, Bostock H, Z'Graggen W, Tan V, Kristensen A, Kristensen R, Larsen L, Zeppelin Z, Tankisi H. ‌Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties. J Vis Exp. 2020;156:e60788.
  3. Ranza E, Z'Graggen W, Lidgren M, Beghetti M, Guipponi M, Antonarakis S, Absoud M, Goyal S, Pal D, Korff C. ‌SCN8A heterozygous variants are associated with anoxic-epileptic seizures. Am J Med Genet A. 2020 Feb;182(5):1209-1216.
  4. Mija R, Zubak I, Schütz A, Glas M, Fung C, Jakob S, Beck J, Z'Graggen W, Bloch A. ‌Correlation of optic nerve and optic nerve sheath diameter with intracranial pressure in pigs. PLoS One. 2020 Feb 4;15(2):e0228242.
  5. Hakim A, Pastore-Wapp M, Vulcu S, Dobrocky T, Z'Graggen W, Wagner F. ‌Efficiency of Iterative Metal Artifact Reduction Algorithm (iMAR) Applied to Brain Volume Perfusion CT in the Follow-up of Patients after Coiling or Clipping of Ruptured Brain Aneurysms. Sci Rep. 2019 Dec 19;9(1):19423.
  6. Fischer C, Goldberg J, Vulcu S, Wagner F, Schöni D, Söll N, Hänggi M, Schefold J, Fung C, Beck J, Raabe A, Z'Graggen W. ‌ Nimodipine-Induced Blood Pressure Changes Can Predict Delayed Cerebral Ischemia Front Neurol. 2019 Oct 31;10:1161.
  7. Cipriani D, Rodriguez B, Häni L, Zimmermann R, Fichtner J, Ulrich C, Raabe A, Beck J, Z'Graggen W. ‌Postural changes in optic nerve and optic nerve sheath diameters in postural orthostatic tachycardia syndrome and spontaneous intracranial hypotension: A cohort study PLoS One. 2019 Oct 9;14(10):e0223484.
  8. Eyding J, Reitmeir R, Oertel M, Fischer U, Wiest R, Gralla J, Raabe A, Zubak I, Z'Graggen W, Beck J. ‌Ultrasonic quantification of cerebral perfusion in acute anterior circulation occlusive stroke-A comparative challenge of the refill- and the bolus-kinetics approach PLoS One. 2019 Aug 15;14(8):e0220171.
  9. Fichtner J, Häni L, Raabe A, Z'Graggen W. ‌Normaldruck-Hydrozephalus Swiss Med Forum. 2019;19(2930):476-480
  10. Häni L, Fichtner J, Raabe A, Z'Graggen W. ‌Intrakranieller Druck Swiss Med Forum. 2019;19(2728):441-448
  11. Rodriguez B, Zimmermann R, Gutbrod K, Heinemann D, Z'Graggen W. ‌Orthostatic Cognitive Dysfunction in Postural Tachycardia Syndrome After Rapid Water Drinking Front Neurosci. 2019 Apr 9;13:327.
  12. Schucht P, Fischer U, Fung C, Bernasconi C, Fichtner J, Vulcu S, Schöni D, Nowacki A, Wanderer S, Eisenring C, Krähenbühl A, Mattle H, Arnold M, Söll N, Tochtermann L, Z'Graggen W, Jünger S, Gralla J, Mordasini P, Dahlweid F, Raabe A, Beck J. ‌Follow-up Computed Tomography after Evacuation of Chronic Subdural Hematoma N Engl J Med. 2019 Mar 21;380(12):1186-1187.
  13. Baschera D, Jäger D, Preda R, Z'Graggen W, Raabe A, Exadaktylos A, Hasler R. ‌Comparison of the Incidence and Severity of Traumatic Brain Injury Caused by Electrical Bicycle and Bicycle Accidents—A Retrospective Cohort Study From a Swiss Level I Trauma Center World Neurosurg. 2019 Jun;126:e1023-e1034.
  14. Schefold J, Messmer A, Wenger S, Müller L, von Haehling S, Doehner W, McPhee J, Fux M, Rösler K, Scheidegger O, Olariu R, Z'Graggen W, Rezzi S, Grathwohl D, Konz T, Takala J, Cuenoud B, Jakob S. ‌Nutrient pattern analysis in critically ill patients using Omics technology (NAChO) – Study protocol for a prospective observational study Medicine (Baltimore). 2019 Jan;98(1):e13937.
  15. Goldberg J, Schöni D, Mordasini P, Z'Graggen W, Gralla J, Raabe A, Beck J, Fung C. ‌Survival and Outcome After Poor-Grade Aneurysmal Subarachnoid Hemorrhage in Elderly Patients. Stroke. 2018 Dec;49(12):2883-2889.
  16. Z'Graggen W, Schefold J. ‌Critical illness myopathy: Glucocorticoids revisited? Acta Physiol (Oxf). 2019 Feb;225(2):e13205.
  17. Vulcu S, Wagner F, Fernandes Santos A, Reitmeir R, Söll N, Schöni D, Fung C, Wiest R, Raabe A, Beck J, Z'Graggen W. ‌Repetitive Computed Tomography Perfusion for Detection of Cerebral Vasospasm–Related Hypoperfusion in Aneurysmal Subarachnoid Hemorrhage World Neurosurg. 2019 Jan;121:e739-e746.
  18. Beck J, Häni L, Ulrich C, Fung C, Jesse C, Piechowiak E, Z'Graggen W, Meier N, Raabe A. ‌Diagnostic challenges and therapeutic possibilities in spontaneous intracranial hypotension. Clinical and Translational Neuroscience. 2018 July-December;2(2);1-11.
  19. Fichtner J, Ulrich C, Fung C, Cipriani D, Gralla J, Piechowiak E, Schlachetzki F, Z'Graggen W, Raabe A, Beck J. ‌Sonography of the optic nerve sheath diameter before and after microsurgical closure of a dural CSF fistula in patients with spontaneous intracranial hypotension - a consecutive cohort study. Cephalalgia. 2019 Feb;39(2):306-315.
  20. Heldner M, Jung S, Fischer U, Hänggi M, Z'Graggen W, Arnold M. ‌Akuter ischämischer Hirnschlag Swiss Med Forum. 2018;18(3031):611-617
  21. Hakim A, Vulcu S, Dobrocky T, Z'Graggen W, Wagner F. ‌Using an orbit shield during volume perfusion CT: is it useful protection or an obstacle? Clin Radiol. 2018 Sep;73(9):834.e1-834.e8.
  22. Graf N, Mafalda Fernandes Santos A, Ulrich C, Fung C, Raabe A, Beck J, Z'Graggen W. ‌Clinical symptoms and results of autonomic function testing overlap in spontaneous intracranial hypotension and postural tachycardia syndrome: A retrospective study Cephalalgia Reports. 2018 January;1;1-6.
  23. Nowacki A, Wagner F, Söll N, Hakim A, Beck J, Raabe A, Z'Graggen W. ‌Preliminary Results of Emergency Computed Tomography-Guided Ventricular Drain Placement-Precision for the Most Difficult Cases World Neurosurg. 2018 Jun;114:e1290-e1296.
  24. Z'Graggen W, Pollo C. ‌Monitoring of Brain Function in Neurointensive Care: Current State and Future Requirements Monitoring of Brain Function in Neurointensive Care: Current State and Future Requirements. In: Crocco L., Karanasiou I., James M., Conceição R. (eds) Emerging Electromagnetic Technologies for Brain Diseases Diagnostics, Monitoring and Therapy. Springer, Cham. 2018;1-6.
  25. Schär R, Schwarz C, Söll N, Raabe A, Z'Graggen W, Beck J. ‌Early Postoperative Perils of Intraventricular Tumors: An Observational Comparative Study World Neurosurg. 2018 May;113:e769-e776.
  26. Boërio D, Corrêa T, Jakob S, Ackermann K, Bostock H, Z'Graggen W. ‌Muscle membrane properties in A pig sepsis model: Effect of norepinephrine Muscle Nerve. 2018 May;57(5):808-813.
  27. Tan V, Z'Graggen W, Hanna M, Bostock H. ‌In vivo assessment of muscle membrane properties in the sodium channel myotonias Muscle Nerve. 2018 Apr;57(4):586-594.
  28. Beck J, Fung C, Ulrich C, Fiechter M, Fichtner J, Mattle H, Mono M, Meier N, Mordasini P, Z'Graggen W, Gralla J, Raabe A. ‌Cerebrospinal fluid outflow resistance as a diagnostic marker of spontaneous cerebrospinal fluid leakage J Neurosurg Spine. 2017 Aug;27(2):227-234.
  29. Z'Graggen W, Solà R, Graf N, Serra J, Bostock H. ‌Sensitivity to ischaemia of single sympathetic nerve fibres innervating the dorsum of the human foot J Physiol. 2017 Jul 1;595(13):4467-4473.
  30. Andereggen L, Beck J, Z'Graggen W, Schroth G, Andres R, Murek M, Hänggi M, Reinert M, Raabe A, Gralla J. ‌Feasibility and Safety of Repeat Instant Endovascular Interventions in Patients with Refractory Cerebral Vasospasms AJNR Am J Neuroradiol. 2017 Mar;38(3):561-567.
  31. Beck J, Ulrich C, Fung C, Fichtner J, Seidel K, Fiechter M, Hsieh K, Murek M, Bervini D, Meier N, Mono M, Mordasini P, Hewer E, Z'Graggen W, Gralla J, Raabe A. ‌Diskogenic microspurs as a major cause of intractable spontaneous intracranial hypotension Neurology. 2016 Sep 20;87(12):1220-6.
  32. Reitmeir R, Eyding J, Oertel M, Wiest R, Gralla J, Fischer U, Giquel P, Weber S, Raabe A, Mattle H, Z'Graggen W, Beck J. ‌Is ultrasound perfusion imaging capable of detecting mismatch? A proof-of-concept study in acute stroke patients J Cereb Blood Flow Metab. 2017 Apr;37(4):1517-1526.
  33. Schär R, Fiechter M, Z'Graggen W, Söll N, Krejci V, Raabe A, Beck J. ‌No Routine Postoperative Head CT following Elective Craniotomy--A Paradigm Shift? PLoS One. 2016 Apr 14;11(4):e0153499.
  34. Fung C, Murek M, Klinger-Gratz P, Fiechter M, Z'Graggen W, Gautschi O, El-Koussy M, Gralla J, Schaller K, Zbinden M, Arnold M, Fischer U, Mattle H, Raabe A, Beck J. ‌Effect of Decompressive Craniectomy on Perihematomal Edema in Patients with Intracerebral Hemorrhage PLoS One. 2016 Feb 12;11(2):e0149169.
  35. Tan V, Z'Graggen W, Boërio D, Turner C, Hanna M, Bostock H. ‌In vivo assessment of muscle membrane properties in myotonic dystrophy Muscle Nerve. 2016 Aug;54(2):249-57.
  36. Fung C, Inglin F, Murek M, Balmer M, Abu-Isa J, Z'Graggen W, Ozdoba C, Gralla J, Jakob S, Takala J, Beck J, Raabe A. ‌Reconsidering the logic of World Federation of Neurosurgical Societies grading in patients with severe subarachnoid hemorrhage J Neurosurg. 2016 Feb;124(2):299-304.
  37. Fichtner J, Ulrich C, Fung C, Knüppel C, Veitweber M, Jilch A, Schucht P, Ertl M, Schömig B, Gralla J, Z'Graggen W, Bernasconi C, Mattle H, Schlachetzki F, Raabe A, Beck J. ‌Management of spontaneous intracranial hypotension – Transorbital ultrasound as discriminator J Neurol Neurosurg Psychiatry. 2016 Jun;87(6):650-5.
  38. Wagner F, Hänggi M, Wagner B, Weck A, Weisstanner C, Grunt S, Z'Graggen W, Gralla J, Wiest R, Verma R. ‌The value of susceptibility-weighted imaging (SWI) in patients with non-neonatal hypoxic-ischemic encephalopathy Resuscitation. 2015 Mar;88:75-80.
  39. Fung C, Balmer M, Murek M, Z'Graggen W, Abu-Isa J, Ozdoba C, Hänggi M, Jakob S, Raabe A, Beck J. ‌Impact of early-onset seizures on grading and outcome in patients with subarachnoid hemorrhage J Neurosurg. 2015 Feb;122(2):408-13.
  40. Ackermann K, Bostock H, Brander L, Schröder R, Djafarzadeh S, Tuchscherer D, Jakob S, Takala J, Z'Graggen W. ‌Early changes of muscle membrane properties in porcine faecal peritonitis Crit Care. 2014 Aug 22;18(4):484.
  41. Beck J, Gralla J, Fung C, Ulrich C, Schucht P, Fichtner J, Andereggen L, Gosau M, Hattingen E, Gutbrod K, Z'Graggen W, Reinert M, Hüsler J, Ozdoba C, Raabe A. ‌Spinal cerebrospinal fluid leak as the cause of chronic subdural hematomas in nongeriatric patients J Neurosurg. 2014 Dec;121(6):1380-7.
  42. Schär R, Fiechter M, Z'Graggen W, Raabe A, Beck J. ‌Is Fast Track Management after Elective Cranial Surgery Safe and can it Replace Routine Early Postoperative Computed Tomography? J Neurol Surg A Cent Eur Neurosurg 2014; 75 - p33.
  43. Fichtner J, Jilch A, Stieglitz L, Beck J, Raabe A, Z'Graggen W. ‌Infection rate of emergency bolt-kit vs. non-emergency conventional implanted silver bearing external ventricular drainage catheters Clin Neurol Neurosurg. 2014 Jul;122:70-6.
  44. Tan V, Z'Graggen W, Boërio D, Rayan D, Norwood F, Ruddy D, Howard R, Hanna M, Bostock H. ‌Chloride channels in myotonia congenita assessed by velocity recovery cycles Muscle Nerve. 2014 Jun;49(6):845-57.
  45. Fung C, Murek M, Z'Graggen W, Krähenbühl A, Gautschi O, Schucht P, Gralla J, Schaller K, Arnold M, Fischer U, Mattle H, Raabe A, Beck J. ‌Decompressive Hemicraniectomy in Patients With Supratentorial Intracerebral Hemorrhage Stroke. 2012 Dec;43(12):3207-11.
  46. Bostock H, Tan V, Boërio D, Z'Graggen W. ‌Validity of multi-fiber muscle velocity recovery cycles recorded at a single site using submaximal stimuli Clin Neurophysiol. 2012 Nov;123(11):2296-305.
  47. Bostock H, Baumann C, Humm A, Z'Graggen W. ‌Temperature dependency of human muscle velocity recovery cycles Muscle Nerve. 2012 Aug;46(2):264-6.
  48. Fichtner J, Fung C, Z'Graggen W, Raabe A, Beck J. ‌Lack of Increase in Intracranial Pressure After Epidural Blood Patch in Spinal Cerebrospinal Fluid Leak Neurocrit Care. 2012 Jun;16(3):444-9.
  49. Tan V, Z'Graggen W, Boërio D, Rayan D, Howard R, Hanna M, Bostock H. ‌Membrane dysfunction in Andersen-Tawil syndrome assessed by velocity recovery cycles Muscle Nerve. 2012 Aug;46(2):193-203.
  50. Boërio D, Z'Graggen W, Tan V, Guetg A, Ackermann K, Bostock H. ‌Muscle velocity recovery cycles: Effects of repetitive stimulation on two muscles Muscle Nerve. 2012 Jul;46(1):102-11.
  51. Tuchscherer D, Z'Graggen W, Passath C, Takala J, Sinderby C, Brander L. ‌Neurally adjusted ventilatory assist in patients with critical illness-associated polyneuromyopathy Intensive Care Med. 2011 Dec;37(12):1951-61.
  52. Fung C, Z'Graggen W, Beck J, Gralla J, Jakob S, Schucht P, Raabe A. ‌Traumatic subarachnoid hemorrhage, basal ganglia hematoma and ischemic stroke caused by a torn lenticulostriate artery Acta Neurochir (Wien). 2012 Jan;154(1):59-62.
  53. Humm A, Bostock H, Troller R, Z'Graggen W. ‌Muscle ischaemia in patients with orthostatic hypotension assessed by velocity recovery cycles J Neurol Neurosurg Psychiatry. 2011 Dec;82(12):1394-8.
  54. Z'Graggen W, Bostock H. ‌Die Methode der Nervenexzitabilitätsmessung Klinische Neurophysiologie 2011; 42(3): 149-155.
  55. Ackermann K, Z'Graggen W, El-Koussy M, Caversaccio M, Vajtai I, Colucci G. ‌Blindness in a patient with chronic lymphocytic leukemia Am J Hematol. 2011 Sep;86(9):783-4.
  56. Schmittinger C, Schär R, Fung C, Z'Graggen W, Nauer C, Dünser M, Jung S. ‌Brainstem hemorrhage after neural therapy for decreased libido in a 31-year-old woman J Neurol. 2011 Jul;258(7):1354-5.
  57. Z'Graggen W, Brander L, Tuchscherer D, Scheidegger O, Takala J, Bostock H. ‌Muscle membrane dysfunction in critical illness myopathy assessed by velocity recovery cycles Clin Neurophysiol. 2011 Apr;122(4):834-41.
  58. Kaelin-Lang A, Conforto A, Z'Graggen W, Hess C. ‌Poisson distribution to analyze near-threshold motor evoked potentials Muscle Nerve. 2010 Nov;42(5):825-8.
  59. Z'Graggen W, Hess C, Humm A. ‌Acute fluid ingestion in the treatment of orthostatic intolerance – important implications for daily practice Eur J Neurol. 2010 Nov;17(11):1370-6.
  60. Gast H, Schindler K, Z'Graggen W, Hess C. ‌Improvement of non-paraneoplastic voltage-gated potassium channel antibody-associated limbic encephalitis without immunosuppressive therapy Epilepsy Behav. 2010 Apr;17(4):555-7.
  61. Z'Graggen W, Aregger F, Farese S, Humm A, Baumann C, Uehlinger D, Bostock H. ‌Velocity recovery cycles of human muscle action potentials in chronic renal failure Clin Neurophysiol. 2010 Jun;121(6):874-81.